I am serving as the co-investigator/collaborator, and providing bioinformatics supports for these projects:

Active


Title: Mechanism and therapeutic targeting of castration resistance in SPOP-mutated prostate cancer

Title: Determine the Microphthalmia Transcription Factor (MITF)-regulated cell rewiring mechanisms in lethal prostate cancer

Title: Alliance Statistics and Data Management Center Grant

Title: Spatially-resolved protein and transcriptome mapping of senescent cells

Title: Cooperativity of TMPRSS2-ERG fusion with p53 inactivation in prostate cancer pathogenesis

Title: Role of proinflammatory cytokine-induced AR degradation in castration-resistant prostate cancer

Title: Mechanism and role of aberrant AR activity in castration-resistant prostate cancer

Title: Understanding the interactions between germline and somatic alterations in the pathogenesis of gliomas

Title: Epigenetic Mechanisms Underlying Hepatitis C-Induced Hepatocarcinogenesis

Title: Discovery and validation of non-invasive epigenetic biomarkers for AATD liver disease

Title: Identify the genomic biomarkers of migraine

Title: Single-cell transcriptional and epigenomic dissection to identify therapeutic targets for ALS and FTD.

Title: Epigenetic Heterogeneity as a Driver of Liver Disease and Cancer

Completed


Title: The role of EZH2 in PTEN-deficient prostate cancer pathogenesis and therapy

Title: Targeting aberrant AR-FL and AR-V expression and activity to overcome therapy resistance in metastatic castration-resistant prostate cancer

Title: Mechanism of Action and Disease Relevance of Androgen Receptor-Bound Enhancer RNAs (AR-eRNAs) in Prostate Cancer

Title: Role of RUNX2 in prostate cancer intratumoral androgen synthesis and progression

Title: Role of FOXO1 Inactivation in Prostate Tumorigenesis

Title: Epigenetic Mechanisms Underlying Hepatitis C-Induced Hepatocarcinogenesis

Title: Deciphering the interplay between H3K36 and DNA methylation in renal cancer